There are few therapeutic options for coronary vascular disease (CVD), despite it being the leading cause of death worldwide. The minimal regenerative capacity of the adult human heart is an important roadblock in the treatment of CVD. Species capable of effective cardiac regeneration rely on fast revascularization to supply nutrients and restore oxygen to the injured area (1). Thus, a better understanding of the developmental processes that guide the formation of coronary vasculature could help in the development of better therapies to assist the formation of new vessels.